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HEXAGHEN- The Next Generation of Bodybuilding Freaks Are Coming!
Increases IGF-1 up tp 12,000 ng/dl
The development of HEXAGHEN, the first ever orally effective maximum threshold IGF-1 activator, is going to breed a new generation of monstrous bodybuilders. Scientists have proclaimed IGF-1 to be the �new holy grail to muscle growth�. It poses extremely anabolic actions and is the critical mediator of muscle growth as it stimulates both the differentiation and proliferation of myoblasts (muscle cells). In general terminology, this means that IGF-1 has the ability to actually increase not only the size but also increase the number of muscle cells.
IGF-1 also enhances muscle growth by increasing amino acid uptake and protein synthesis. With the discovery of IGF-1�s powerful anabolic effects, world-class bodybuilders quickly sought out a means to directly increase IGF-1 through recombinant IGF-1 injections. Most are reporting 20 to 30 pound gains of lean muscle in just 3 months.
Now, through the development of HexaGHen, you can experience the extreme anabolic effects of IGF-1. Amazing never before seen 12,000% increases in
IGF-1 are being reported. HexaGHen's maximum threshold IGF-1 output triggers extremely anabolic muscle cell hyperplasia and stimulates muscle cell growth. HexaGHen�s efficacy is made possible through the utilization of a unique combination of highly specialized actives, which includes a GHRP-2 hexapeptide and an IGFBP-3 inhibitor. These advanced compounds are administered in a patent pending Fastsorb tablet delivery.
The Fastsorb tablet provides oral mucosal delivery, which is critical for these potent yet fragile compounds to be absorbed directly into the bloodstream, bypass the gastrointestinal tract and first-pass metabolism in the liver thereby preserving their activity and effectiveness as an IGF-1 Activator. HexaGHen is clearly the most exciting muscle-building breakthrough on the bodybuilding circuit today.
ZRT Laboratory Tested*
Scientists at MuscleMeds selected ZRT laboratory to validate the IGF-1 elevating effects of HEXAGHEN. ZRT test results revealed IGF-1 levels were increased upto 12,000 ng/dl above baseline by the end of the 14 day study period. These supra-physiological levels of IGF-1 allow for maximum tissue saturation and powerful anabolic effects, including an essential role in promoting muscle tissue growth.
For this study, initial blood samples were taken prior to Hexaghen administration and following 7 days and 14 days continuous Hexaghen administration. Subjects took just one, 12.6mg Hexaghen FastSorb tablet every night 30 minutes before bedtime for 14 continuous days. Based on the ZRT Laboratory results, Hexaghen was shown to stimulate supra-physiological levels of IGF-I important for maximum tissue saturation and production of anabolic muscle growth effects. During the study period IGF-I levels were maintained significantly higher than before using Hexaghen.
THE SCIENCE BEHIND HEXAGHEN
DESCRIPTION: Hexaghen Fastsorb tablets belong to a new class of orally effective IGF-1 (Insulin-Like Growth Factor-1) stimulating compounds. Hexaghen is designed to stimulate the endogenous production of IGF-1, causing a quick and dramatic rise in serum free IGF-1 levels. The Hexaghen IGF-1 Optimizing complex modulates critical endocrine functions, and promotes prolonged elevation of serum IGF-1 levels for progressive anabolic muscle growth benefits. Hexaghen utilizes a patent pending FASTSORB sub-buccal delivery system for rapid absorption and maximum bioavailability.
ACTIVE COMPOUNDS:
Hexaghen, sub-buccal tablets for oral administration contain IGF-1 Optimizing synergistic compounds:
- GHRP-2 Hexapeptide Acetate
- cis -4, 17(20)-pregnadiene-3,16-dione
- trans-4, 17(20)-pregnadiene-3,16-dione
CLINICAL PHARMACOLOGY: IGF-1 poses some unique anabolic characteristics and is one of the most potent natural activators of the AKT signaling pathway, a stimulator of cell growth and multiplication. Attention was first turned to IGF-1 when scientists researching growth hormone discovered that GH�s influence on IGF-1 was the responsible factor for the anabolic effects associated with growth hormone administration and elevation. In fact, while GH has direct fat burning effects as it metabolizes stored body fat, its muscle building effects are actually attributed to its effects on increasing IGF-1 levels. Therefore, it is IGF-1 and not GH that directly mediates muscle cell hyperplasia and muscle growth at the cellular level. IGF-1 is thought to be the critical mediator as it stimulates both the differentiation and proliferation of myoblasts (muscle cells), resulting in muscle growth. IGF-1 also enhances muscle growth by increasing amino acid uptake and protein synthesis.
Hexaghen's active compounds work synergistically to rapidly stimulate GH production, which promotes synthesis of IGF-1, increasing both total and free IGF-1 levels. IGF-1 is an important peptide hormone that is involved in regulating growth and development of muscle tissue. Its primary action is mediated by binding to specific IGF-1 receptors present on many cell types in many tissues. The free form IGF-1 fraction is highly bio-active in comparison to the IGF-1 bound to IGF Binding Proteins (IGFBPs). IGF-1 is the principal hormonal mediator of growth in the body. In the cascade of events leading to a surge in IGF-1 production and levels, Hexaghen stimulated growth hormone is metabolized by the liver and poteniates the synthesis and secretion of IGF-1.
Muscle tissue has an abundance of IGF-1 receptors. When serum IGF-1 binds to these receptor sites on muscle tissue, it stimulates the following anabolic actions and growth processes in humans, including increasing the number and size of muscle cells:
- Regulator of cell growth and development.
- Regulator of cellular DNA synthesis.
- Mediates muscle cell hyperplasia and muscle fiber development initiation and maturation.
- Stimulates the growth and size of muscle cells.
- Stimulates glucose uptake by myoblasts (muscle precursor cells), which fuels their growth and development into muscle fiber cells.
- Increases muscle cell uptake of amino acids, uses as building blocks of muscle protein molecules.
- Increases nitrogen retention and a greater food conversion efficiency.
- Reduces nitrogen excretion.
- Improves wound healing.
- Stimulates muscle protein synthesis.
- Preferentially stimulates the growth of lean tissue.
- Stimulates mitogenic (cell replication) activities that lead to an increased number of muscle cells in the body.
- Vital for muscle repair and regeneration.
- Causes improvements in body composition, demonstrating a decrease in body fat mass and a profound increase in lean body mass.
The relationship within the endocrine / IGF-1 axis is a complex system. Scientists have recently identified other factors that play a critical role in effecting IGF-1 levels. Approximately 98% of IGF-1 is bound to one of several insulin-like growth factor binding proteins (IGFBP). IGFBP-3, the most abundant protein, accounts for 80% of all IGF-1 binding. Research has demonstrated that reducing IGF-1 binding proteins and maintaining higher levels of free IGF-1 is correlated to improved anabolic effects and muscle development. Hexaghen�s IGF-1 optimizing action also involves the sustained stimulation of thyroid hormone production, which mediates IGFBP levels, favorable to achieving sustainable high free IGF-1 levels to further enhance muscle growth.
Thyroid function is associated with enhancing IGF-1 bio-active tissue levels and further increasing the rate of protein synthesis. As IGF-1 levels are increased, a series of negative feedback controls involving the thyroid endocrine axis are triggered to keep IGF-1 levels within a narrow physiological range. From examining the relationships between GH, IGF-1 production, IGF-1 levels, free IGF-1, IGFBP, and thyroid function, MuscleMeds researchers determined a correlation between IGF-1 production and bio-effectiveness related to thyroid stimulation. Hexaghen�s synergistic thyroid involvement results in sustaining higher total and free IGF-1 levels for longer periods of time, thereby extending the overall desired IGF-1 anabolic effects.
Research and Development
The muscle building effects of IGF-1 have been well known and medically documented for years. But, the controlling factors regulating the body's natural output have challenged researchers. Synthetic IGF-1 has been produced by major biotech pharmaceutical companies on a large scale using recombinant DNA technology. These synthetic forms must be administered via injection dosing. The development of an orally effective IGF-1 enhancing compound has long been a major global objective of biotechnologists.
After years of extensive research and laboratory analysis, MuscleMeds researchers discovered a unique IGF-1 stimulating hexapeptide (GHRP-2 Hexapeptide Acetate). This unique six chain peptide was found to have potent IGF-1 stimulating effects, based on using injection dosing. The development of an effective oral dosage form for GHRP-2 Hexapeptide posed some biotechnical challenges. The first challenge was the stability and effectiveness when administered orally, because conventional oral dosing (such as tablets, capsules, liquids and softgels) was ineffective due to the gastrointestinal destruction of the GHRP-2 hexapeptide. As with other peptide substances, GHRP-2 hexapetide is subject to destruction (breakdown) in the gastrointestinal system, which eliminates the effectiveness and ability to reach the hypothalamus-pituitary axis. In order to create a product that is suitable for oral administration of the Hexaghen GHRP-2 Hexapeptide acetate, MuscleMeds scientists employed the utilization of their proprietary FastSorb sub-buccal delivery system technology. MuscleMeds� testing using Hexaghen Fastsorb tablets proved to be the viable solution for providing a maximally effective oral delivery dosage system. The fastsorb tablet dosage form allows for the long hexapeptide to bypass degradation and be absorbed in the buccul cavity directly into the blood stream to stimulate the hypothalamus-pituitary GH / IGF-1 axis.
The next challenge was to manipulate endocrine functions at the GH/IGF-1 Axis to override the negative feedback inhibition of IGFBP-3 (Insulin-Like Binding Growth Factor Protein-3) to supercede the narrow physiological range and achieve the maximum IGF-1 output threshold. Approximately 98% of IGF-1 is typically bound to one of 6 binding proteins (IGFBP). IGFBP-3, the most abundant protein, accounts for 80% of all IGF binding. This means that most of the IGF-1 that you produce is bound to IGFBP-3 and not able to bind to specific IGF-1 receptors present on muscle cells and carry out its anabolic actions. To overcome this MuscleMeds researchers found that there was a direct correlation between TSH (Thyroid Stimulating Hormone) and IGFBP-3.
As a result of this researched based product development effort, Hexaghen features a unique IGF-1 Optimizing Complex. Hexaghen's novel ingredient composition and proprietary pharmaceutical based liposomal sub-buccal delivery system, stabilizes the bioactives for rapid and high levels of absorption directly into the blood stream primarily through buccal cavity (mouth) absorption. Oral mucosal dosage delivery (transmucosally) is an alternative method of systemic nutrient delivery, which offers several advantages as the oral mucosa is highly vascularised with absorptive abilities. Therefore, Hexaghen�s active compounds are absorbed through the oral mucosa directly enter the bloodstream, bypassing the gastrointestinal tract and first-pass metabolism in the liver. This improves the bioeffectiveness of delivery into the body, making it possible to maximally stimulate the levels of IGF-1 through a series of endocrine medicated events: Hexaghen stimulates GHRP, GH, and IGF-1 levels, modulates thyroid function, and decreases IGFBP for the attainment of maximum threshold IGF-1 output. Hexaghen's ability to significantly increase free IGF-1 levels exerts extremely powerful anabolic effects by directly mediating muscle cell differentiating, proliferation, and hyperplasia.
Interactions with Testosterone: The Increased Anabolic Effects of Combining IGF-1 with Testosterone
Scientific evidence supports that elevated IGF-1 levels combined with elevated testosterone levels yield even greater muscle hypertrophy. IGF-1's role as a critical mediator of muscle growth by stimulating both muscle cell hyperplasia (an increase in number of muscle cells) and muscle hypertrophy (muscle cell growth) makes it the most effective muscle-building hormone. When combined with testosterone, another powerful hormone, which induces anabolic muscle hypertrophy, muscle building is further enhanced. The dual hypertrophic (muscle building) effects of IGF-1 and testosterone allow for the newly formed IGF-1 stimulated muscle cells to develop, mature and grow. The synergistic effects of having more muscles cells and having these muscle cells grow at a faster rate results in a significant gain in lean body mass.
An optimal program for muscle growth would be to combine HexaGHen with MuscleMEDs� pharmadynamic testosterone optimizer ARIMATEST. ARIMATEST is an anti-aromatase inhibitor with very powerful testosterone elevating effects, made possible through the utilization of advanced anti-aromatase bioactives provided in the advanced sub-buccal FASTSORB delivery tablet. Arimatest has the unique ability to rapidly and dramatically increase free testosterone while eliminating estrogen through aromatase inhibition. ARIMATEST is for use by adult males only.
Supplement Facts
Serving Size 2 Tablets
Servings Per Container 28
Amount Per Serving % DV
HEXAGHEN 12.60 mg **
[Patent Pending IGF-1 complex of Ketonic Isomers (cis and trans-4 17(20)-pregnadiene-3,16-dione), GHRP-2 Hexapeptide Acetate] **
** Daily Value (DV) not established
Other Ingredients:
Lactose, Mannitol, methylcarboxy cellulose, Phosphatidyl Choline, EDTA natural and artificial citrus flavors, Palmitic Acid, Phosphatidyl Serine, calcium carboxycellulose, FD&C Red #40
Storage Instructions:
Store at a controlled room temperature of 15-30C/59-86F
INDICATIONS AND USAGE
Hexaghen is intended for use by individuals over the age of 18 to help increase IGF-1 levels, for the promotion and stimulation of lean muscle tissue, when used in conjunction with proper nutrition, strength training, and muscle building programs.
DOSAGE AND ADMINISTRATION
Directions:
Hexaghen Fastsorb tablets are designed to be dissolved slowly in the mouth for sub-buccal absorption. Hexaghen should be taken 30 minutes before bedtime. Place two (2) Hexaghen Fastsorb tablets under your tongue and let dissolve completely, then swallow.
Do Not Exceed Two (2) Tablets Per Day.
6 Week Cycling Instructions
2 Weeks on (14 days)
1 Week off (7 days)
2 Weeks on (14 days)
1 Week off (7 days)
(Then Repeat Cycle)
WARNINGS:
Not for use by individuals under the age of 18 years. Do not use if pregnant or nursing. Consult a physician or licensed qualified health care professional before using this product. Do not exceed recommended serving. Discontinue use and call a physician or licensed qualified health care professional immediately if you experience any adverse effects. To report any adverse event call 1-800-332-1088.
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